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December 15, 2021
By Brock Pierce and Shellie Edge

As we reflect on 2021, our Innovate Carolina team feels inspired by the many UNC innovators and entrepreneurs with whom we’ve had the opportunity to collaborate this year. Over the past 12 months, our faculty, students, alumni and community partners have found countless ways of using their ingenuity to move the world forward during some of the most challenging scientific, social and economic times. And with each step forward, they’ve brought us closer to the human progress we aspire to achieve: helping our communities and the people who live in them work smarter and live better. Many ideas and inventions advanced by Carolina innovators this year are already making a positive difference. Others are poised to make their mark as we step into 2022.

As this year concludes, members of our Innovate Carolina team share reflections on a few of the many projects and initiatives pursued by Carolina innovators that captured our imaginations in 2021. Such bold endeavors give us immense hope for the innovative possibilities that lie ahead. 

Want to help faculty and student innovators make a social and economic impact? Consider making a gift to the Innovate Carolina General Fund or  Carolina Startup Connect Program (formerly Dreamers-Who-Do).


Michelle Bolas
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“I’m so inspired by faculty, students and members of the community who continue to innovate by using a problem-solving mindset to address issues that Carolina is poised to solve and that matter to the world. The future holds tremendous promise for the University to continue taking breakthrough technologies to market that can change lives and launching new startups and ventures that help drive local communities and their economies. By valuing the relationships built among campus programs and community partners, we can all innovate in new ways and make a greater impact together than we can make by ourselves. ”
Michelle Bolas, Interim Vice Chancellor, Innovation, Entrepreneurship and Economic Development

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Mapping global systems and social solutions

In 2021, four teams competed in the UNC-Chapel Hill campus finals of the global Map the System Competition. The Rising Waters team, which explore inequalities in community resiliency to flooding in eastern North Carolina, was selected to represent the University in the Map the System Global Finals.

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“The Map the System competition allows students to deeply explore an issue that matters to them. By asking students to think differently about social and environmental change, this experience gives students a critical 21st century skillset in understanding the complexity of problems they would like to solve through the lens of systems thinking. I am hopeful for the future as students explore, learn and apply a systems approach to their work and begin to break down the role of power structures, policies, markets, networks and culture in big and small ways.”
Melissa Carrier, Director, Office of Social Innovation, Innovate Carolina

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HIV cure heads to human trials

Pharma giant GlaxoSmithKline is preparing to start human trials of an HIV cure in a groundbreaking leap which could finally rid millions of the virus. The British drugs titan hopes to start human trials on a potential cure for the disease as soon as next summer. A GSK spokesman said: “One of the other exciting partnerships is the unique industry/academic partnership we have with the University of North Carolina at Chapel Hill and the creation of a biotech called QURA. Our scientists work side by side with UNC scientists at the HIV Cure Center, in the same lab, combining their early science expertise with our drug development expertise to find a cure for HIV.” (The Mail)

Bryant Moore
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“Building relationships with industry and connecting UNC startups to investors, tech partners and advisors is what drives me. Watching a startup grow is tremendous, and knowing your team had a small part of that growth brings great joy to my job each day. Looking ahead, I am excited to continue to engage our industry partners, positively impacting the innovation and entrepreneurship community here at Carolina and beyond.”
Bryant Moore, Director of Strategic Partnerships, UNC Office of Technology Commercialization

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Next-gen startup problem solvers

How are a new group of UNC graduate students and postdoctoral fellows accelerating the pace of progress for faculty inventors-turned-entrepreneurs? These new startup problem solvers are working through the Venture Catalyst Program to move breakthrough therapies, disruptive treatments and novel technologies from lab to real life.

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“Since our launch of the Venture Catalyst Program in 2020, we have supported 18 remarkable innovators and 20 diligent entrepreneurial trainees across UNC-Chapel Hill. Through dedicated mentorship, experiential learning and tailored curriculum, our program has enabled entrepreneurs to reach critical business development milestones within the span of six months. We are thoroughly impressed with the ongoing progress of our cohorts and look forward to supporting the Carolina community as the program grows.”
Judy Prasad, Operations and Program Manager, Venture Catalyst Program Lead, KickStart Venture Services

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Downtown Chapel Hill innovation district accelerates on the heels of new partnerships

The recent return of students to Chapel Hill — and the added buzz of activity that they bring to downtown — aren’t the only changes you’re likely to notice around town. Chancellor Kevin M. Guskiewicz and Town of Chapel Hill Mayor Pam Hemminger announced a series of steps that the University and town are taking to increase the economic vibrancy of downtown Chapel Hill.

Sheryl Waddell
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“We’ve made a lot of progress laying the groundwork for the innovation district and are on track for a 2022 opening of the hub. Our relationship with BioLabs continues to evolve to ensure we are leveraging our assets to meet the needs of UNC life science startups. Meanwhile, we’re also establishing relationships with alumni, businesses and other strategic partners through innovation programming.”
Sheryl Waddell, Interim Director of Economic Development, Innovate Carolina

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The Office of Technology Commercialization works to realize the full potential of Carolina innovations

The Office of Technology Commercialization works to accelerate the translation of important ideas into meaningful products and services for the benefit of North Carolina, the world and the University. Working to realize the full potential of UNC-Chapel Hill innovations, the OTC team helps manage the identification, evaluation, protection, translation and commercialization of impactful inventions and technologies. The team also helps find resources, identify partners in industry and business, as well as provides services, training and mentorship to promote entrepreneurship and startup company formation.

Champ Gupton
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“I have the pleasure of working daily with an amazing group of faculty and tech transfer professionals at UNC. What I enjoy most is engaging with these individuals at the cutting edge of technology development and commercialization. During my tenure at UNC, I have had the pleasure of working with a number of faculty startups working to commercialize UNC technologies. I enjoy it most when these fledgling companies are able to move from that early incubator stage into the commercialization of product or service that will benefit society.”
Champ Gupton, Commercialization Manager, UNC Office of Technology Commercialization

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Students and ventures meet at Carolina Startup Connect 

More than 30 startup companies visited the UNC-Chapel Hill campus for Carolina Startup Connect 2021 (formerly Dreamers-Who-Do) to meet with Carolina students. This experience included multiple meet-and-greet events that gave both students and local startup companies the chance to network, share mutual professional goals, and explore internship and skill-building opportunities together. Here’s a preview of just a few of the fast-growing ventures that participated.

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“It was great to network in person at Carolina Startup Connect. We had 150 interested students representing more than half of UNC’s majors, the most students registered for these meet-and-greet events since 2018. Shifting the location to the center of campus created a beautiful backdrop for students to learn more about these startup companies as well as internship opportunities. It’s amazing to be able to help local startups and students find what they need in each other.”
Kimi Yingling, Student Engagement and Events Program Manager, Innovate Carolina

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UNC-Chapel Hill selected for esteemed national Innovation Corps program

The National Science Foundation named UNC Chapel Hill an I-Corps site, part of a larger effort to scale the national innovation network to rapidly advance solutions that benefit society. The prestigious designation positions Carolina to deliver focused entrepreneurship training and customer discovery research as part of a larger national effort.

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“We are thrilled that UNC was selected to become an Innovation Corps site. The program will help our innovators significantly refine their commercialization plans and support well-informed pivots to their commercialization strategies based on market feedback, ultimately driving more translation of university research, economic value and societal impact. We are also excited to collaborate with other world-class institutions to design a new curriculum and promote participation across diverse communities of innovators.”
Mireya McKee, Interim Director, KickStart Venture Services

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Breakthrough gene therapies in sight

Patients with genetic lysosomal storage diseases are living longer because of better treatments. But with promising advances and longer lives comes complications, like the loss of eyesight, as these rare diseases take their toll over time. UNC-affiliated startup RainBio is changing the landscape of ocular gene therapy with its novel treatment to reverse and prevent blindness in children with rare genetic disease.

Kelly Parsons
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“My ultimate goal and passion is to see research make a tangible difference in people’s lives. It has been a pleasure to participate in the evolution of gene therapy here at UNC and beyond, as it is not often we can move forward on an opportunity to eradicate a patient’s symptoms or even cure their disease. As more gene therapies developed at UNC advance to the clinic, I am excited to support and partner with our scientists and commercial collaborators as they continue to innovate to expand the impact of these technologies.”
Kelly Parsons, Associate Director of Technology Commercialization, UNC Office of Technology Commercialization

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Five years in, Carolina Angel Network keeps turning startups out

With five years down and countless investments to go, the Carolina Angel Network continues to help early-stage startups grow and flourish by providing advice, networks and capital that startups need to be well positioned for success. In CAN’s brief five-year history, it has supported more than 20 startups, with members investing more than $20 million and generating more than $108 million in revenue for the startups.

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“We want to help grow early-stage companies to a point where they can launch themselves into sizable businesses and look for exit opportunities. Bringing together the UNC educational community and the UNC alumni network empowers early-stage UNC new businesses that drive our future. Forging these connections helps make the University stronger and gives us the ability to go from an idea in a maker lab to a product or service that gets $10 million in funding.”
Randy Myer, managing director of Carolina Angel Network

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More than a mindset

Magnifying. Adaptive. Powerful. These are just a few of the words students in the first cohort of the Carolina Graduate Certificate in Innovation for the Public Good use to describe their experiences in the program,  which teaches students about modern changemaking and helps them hone the skills they need to collaborate with others, partner with government, nonprofits, businesses and communities to tackle challenges in new ways.

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“As the inaugural director for CIPG and co-instructor for the HBEH 748: Design Thinking for the Public Good course, I’m excited to see CIPG students integrate design thinking methods into their research and jobs post-graduation. For example, I’m working with a student to combine front-end methods (e.g. interviews, journey maps) into the development and refinement of a participatory disease surveillance solution in Ghana. I look forward to following the careers of our CIPG graduates and am confident they will inspire additional cohorts of CIPG students as well.”
Liz Chen, Design Thinking Lead, Office of Innovate Carolina

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Measuring the impact of startups

The economic impact of startups connected with UNC Chapel Hill continues to grow across North Carolina. A recent analysis conducted by Innovate Carolina, reported the positive effect of UNC-affiliated startups during the past fiscal year as the COVID-19 pandemic dampened local and global economies. The analysis demonstrates how Carolina-based startups work as engines for economic growth, creating jobs and strengthening local economies and communities.

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“We’re proud of the strength and resiliency of our UNC startups and the brilliant ways in which many have pivoted during the pandemic. We continue to support these ventures through our programs and media shares, and we invite them to contact us at any time for assistance opportunities.”
Cindy Reifsnider, Research Analyst, Office of Innovate Carolina

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FDA clears new 3D dental X-ray device based on UNC research

No matter what might trigger a patient’s fears, everyone understands that the faster dental problems can be found, the better. Novel 3D x-ray technology developed through a collaboration between UNC Chapel Hill scientists in the Department of Physics and Astronomy and the Adams School of Dentistry is looking to do just that: identify dental issues earlier with more detail – and less radiation.

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“I am fortunate to be able to work with a great group of faculty, students, and clinicians from many departments across the university. Each day is a new opportunity to learn about cutting edge innovations being developed to address unmet needs. It is rewarding to be a part of the university wide effort to translate these innovations for the public good to products that will provide a benefit to human health.”
Matt Howe, Commercialization Manager, UNC Office of Technology Commercialization